Introduction of gelatin microspheres into an injectable calcium phosphate cement
نویسندگان
چکیده
منابع مشابه
Introduction of gelatin microspheres into an injectable calcium phosphate cement.
For tissue engineered bone constructs, calcium phosphate cement (CPC) has a high potential as scaffold material because of its biocompatibility and osteoconductivity. However, in vivo resorption and tissue ingrowth is slow. To address these issues, microspheres can be incorporated into the cement, which will create macroporosity after in situ degradation. The goal of this study was to investiga...
متن کاملInjectable and macroporous calcium phosphate cement scaffold.
Calcium phosphate cement (CPC) can be molded and self-hardens in vivo to form resorbable hydroxyapatite with excellent osteoconductivity. The objective of this study was to develop an injectable, macroporous and strong CPC, and to investigate the effects of porogen and absorbable fibers. Water-soluble mannitol was used as porogen and mixed with CPC at mass fractions from 0% to 50%. CPC with 0-4...
متن کاملIn vitro growth factor release from injectable calcium phosphate cements containing gelatin microspheres.
To improve the in vivo resorption of an injectable calcium phosphate cement (CPC) for bone tissue engineering purposes, in previous experiments macroporosity was introduced by the in situ degradation of incorporated gelatin microspheres. Gelatin microspheres are also suitable carriers for osteoinductive drugs/growth factors, where release occurs concomitantly with degradation of the hydrogel. I...
متن کاملReinforcement of injectable calcium phosphate cement by gelatinized starches.
Current injectable calcium phosphate bone cements (CPC) encounter the problems of low strength, high brittleness, and low cohesion in aqueous environment, which greatly hinder their clinical applications for loading-bearing bone substitution and minimally invasive orthopedic surgeries. Here, a strategy of using gelatinized starches to reinforce injectable CPC was investigated. Four types of sta...
متن کاملInvestigation of Macroporous Calcium Phosphate Cement Obtained by Foamed Gelatin Polymer
This study deals with the effect of gelatin on physical and mechanical properties of calcium phosphate bone cements. The mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate (DCPA) as the cement powder was mixed with 6 wt% Na2HPO4 solution containing different amount (0, 2, 5 and 8% in w/w) of foamed gelatin as liquid phase. The physical properties were determined in the terms of s...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2008
ISSN: 1549-3296,1552-4965
DOI: 10.1002/jbm.a.31703